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CENP-A and CENP-B collaborate to create an open centromeric chromatin state

2022-07-08

Abstract excerpt

Centromeres, the sites within chromosomes responsible for accurate genome repartitioning, are epigenetically defined via replacement of canonical histone H3 by the histone variant CENP-A forming specific nucleosomes with increased DNA flexibility. In human cells, CENP-A nucleosomes and thus centromeres localize to genomic regions containing extended tandem repeats of alpha-satellite DNA. There, the constitutive ce...

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Literature Corpus work
a5165480-96b6-5423-b599-239d9525598d
DOI
10.1101/2022.07.08.499316
Open publication

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CENP-A and CENP-B collaborate to create an open centromeric chromatin stateDOI 10.1101/2022.07.08.499316
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