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Article

CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.

Cell - 12 Dec 2008

Hori Tetsuya, Amano Miho, Suzuki Aussie, Backer Chelsea B, Welburn Julie P, Dong Yimin, McEwen Bruce F, Shang Wei-Hao, Suzuki Emiko, Okawa Katsuya, Cheeseman Iain M, Fukagawa Tatsuo

Abstract excerpt

Kinetochore specification and assembly requires the targeted deposition of specialized nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A is not sufficient to drive full-kinetochore assembly, and it is not clear how centromeric chromatin is established. Here, we identify CENP-W as a component of the DNA-proximal constitutive centromere-associated network (CCAN) of proteins. We...

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PMID: 19070575
DOI: 10.1016/j.cell.2008.10.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.PMID 19070575Read ↗

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Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosomeSemantic proximity Read ↗

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