Article

Differential TLR-ERK1/2 activity promotes viral ssRNA and dsRNA mimic-induced dysregulated immunity in macrophages

2024-05-25

Abstract excerpt

<h4>ABSTRACT</h4> RNA virus induced excessive inflammation and impaired antiviral interferon (IFN-I) responses are associated with severe disease. This innate immune response, also referred to as ‘dysregulated immunity,’ is caused by viral single-stranded RNA (ssRNA) and double-stranded-RNA (dsRNA) mediated exuberant inflammation and viral protein-induced IFN antagonism. However, key host factors and the underlyi...

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Literature Corpus work: a925a473-1b55-5669-879d-58d262019b43
DOI: 10.1101/2024.05.24.595760

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