Article

Human RNase 2 is essential for macrophage response to viral RNA

2025-12-03

Abstract excerpt

<h4>SUMMARY</h4> RNase 2 is the most abundant human RNase A member in macrophages and its expression is activated upon exposure to viruses. Here, we explored the protein role by co-transcriptomics analysis of wild-type (WT) and RNase 2-knock-out (KO) macrophages in absence/presence of a virus-derived single-stranded RNA (ssRNA40). Results revealed that RNase 2 is key for maintaining cell homeostasis. Lacking RNas...

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Literature Corpus work: 7cd5ad0f-3e2e-5682-899e-36acbb967728
DOI: 10.64898/2025.12.03.691791

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