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Article

TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection

29 Oct 2019

Abstract excerpt

flux that prevented type I IFN responses. Our work demonstrates that in human monocytes, TLR7 and TLR8 triggered different signaling pathways that contribute to distinct phenotypes during RNA virus infection. In addition, we defined individual targets within these pathways that promoted specific T helper and antiviral responses.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31662487
DOI: 10.1126/scisignal.aaw1347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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