Article

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

2023-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses and autoimmune diseases. However, the mechanisms underlying the initiation of the TLR7/8-mediated autoimmune signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated in tissues of lupus prone mice and in the plasma of lupus...

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Literature Corpus work: 96c81cc3-00c4-5cf7-96cf-e1aee37adef8
DOI: 10.1101/2023.09.06.556479

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