Article

IRF7 deficiency increases disease severity independently of TLR7 recognition in Influenza A infection in mice

2026-05-26

Abstract excerpt

Influenza A virus (IAV) remains a major cause of respiratory morbidity and mortality, yet the role of Toll-like receptor 7 (TLR7), an RNA sensor, and its downstream signaling events, such as interferon regulatory factor 7 (IRF7), in IAV infection remain unclear. To address this question, we used single-cell RNA sequencing, genetic mouse models, and immunological analysis. Single -cell transcriptomic profiling of t...

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Literature Corpus work: 33a95701-8fdd-5bca-9e06-1c025b80c6aa
DOI: 10.64898/2026.05.23.727394

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