Article

SARS-CoV-2-associated ssRNAs activate inflammation and immunity via TLR7/8

2021-04-15

Abstract excerpt

The inflammatory and IFN pathways of innate immunity play a key role in both resistance and pathogenesis of Coronavirus Disease 2019 (COVID-19). Innate sensors and SARS-CoV-2-Associated Molecular Patterns (SAMPs) remain to be completely defined. Here we identify single-stranded RNA (ssRNA) fragments from SARS-CoV-2 genome as direct activators of endosomal TLR7/8 and MyD88 pathway. The same sequences induced human...

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Literature Corpus work: d96caf14-dff8-5659-97b2-89bf50eb5b0a
DOI: 10.1101/2021.04.15.439839

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