Article

A sterol-binding pocket in iRhom1 underlies paralog-specific regulation of the sheddase ADAM17

2026-05-01

Abstract excerpt

ADAM17, the major sheddase in mammalian cells, releases membrane-tethered EGFR ligands and inflammatory cytokines, and is a central regulator of cell signalling. The rhomboid pseudoproteases, iRhom1 and iRhom2, function as essential cofactors of ADAM17, controlling its maturation and activation. In contrast to the well-characterized iRhom2, the mechanism and regulation of its ubiquitously expressed paralog iRhom1...

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Literature Corpus work: a90fd0c0-0931-5aa7-9195-2d4624419b47
DOI: 10.64898/2026.04.28.721421

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