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Article

Structural basis for ADAM17 activation by the iRhom1 pseudoprotease.

Cell reports - 26 May 2026

Ungvary Joseph N, Maciag Joseph J, Alnajjar Hala F, Dávila Eliud Morales, Slone Conner E, Thomas Joel E, Rich Maria F, Carazo Sophia A, Ifergan Igal, Perez-Aguilar Jose Manuel, Blobel Carl P, Seegar Tom C M

Abstract excerpt

The a disintegrin and metalloproteinase (ADAM)-17 releases pro-inflammatory cytokines, including tumor necrosis factor-α, and several epidermal growth factor receptor ligands from cells. ADAM17 is post-translationally regulated by the inactive rhomboid pseudoproteases iRhom1 and iRhom2, and dysregulation of this signaling axis contributes to diseases ranging from chronic inflammation to cancer. Here, we present...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42024498
DOI: 10.1016/j.celrep.2026.117309
PMCID: PMC13277793

Genes

ADAM17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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