Article
iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.
Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015
Li Xue, Maretzky Thorsten, Weskamp Gisela, Monette Sébastien, Qing Xiaoping, Issuree Priya Darshinee A, Crawford Howard C, McIlwain David R, Mak Tak W, Salmon Jane E, Blobel Carl P
Abstract excerpt
The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and Adam17(-/-) mice die perinatally with open eyes, like Egfr(-/-) mice. A hallmark feature of ADAM17-dependent EGFR ligand...
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