Article

The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth

2022-04-12

Abstract excerpt

The metalloprotease ADAM17 catalyzes the shedding of key signalling molecules from the cell surface, including the inflammatory cytokine TNF (tumour necrosis factor) and activating ligands of the EGFR (epidermal growth factor receptor). ADAM17 exists within an assemblage called the “sheddase complex” containing a rhomboid pseudoprotease (iRhom1 or iRhom2). iRhoms control multiple aspects of ADAM17 biology, includi...

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Literature Corpus work: d5d9b63e-9845-5e82-8d3b-c502e20632d7
DOI: 10.1101/2022.04.11.487842

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