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Novel functions of inactive rhomboid proteins in immunity and disease

1 Aug 2019

Abstract excerpt

iRhoms are related to a family of intramembrane serine proteinases called rhomboids but lack proteolytic activity. In mammals, there are two iRhoms, iRhom1 and iRhom2, which have similar domain structures and overlapping specificities as well as distinctive functions. These catalytically inactive rhomboids are essential regulators for the maturation and trafficking of the disintegrin metalloprotease ADAM17 from...

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Cell Adhesion Molecules Research
Monoclonal and Polyclonal Antibodies Research
Peptidase Inhibition and Analysis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31369701
DOI: 10.1002/jlb.3vmr0219-069r

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