iRhom2: An Emerging Adaptor Regulating Immunity and Disease

Abstract excerpt

and iRhom1 and iRhom2 in mammals, lack the catalytic center and are hence labelled "inactive" rhomboid family members. In mammals, both iRhoms are involved in maturation and trafficking of the ubiquitous transmembrane protease a disintegrin and metalloprotease (ADAM) 17, which through cleaving many biologically active molecules has a critical role in tumor necrosis factor alpha (TNFα), epidermal growth factor...

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