Article
Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2020
Tang Beiyu, Li Xue, Maretzky Thorsten, Perez-Aguilar Jose Manuel, McIlwain David, Xie Yifang, Zheng Yufang, Mak Tak W, Weinstein Harel, Blobel Carl P
Abstract excerpt
The metalloprotease ADAM17 (a disintegrin and metalloprotease 17) regulates EGF-receptor and TNFα signaling, thereby not only protecting the skin and intestinal barrier, but also contributing to autoimmunity. ADAM17 can be rapidly activated by many stimuli through its transmembrane domain (TMD), with the seven membrane-spanning inactive Rhomboids (iRhom) 1 and 2 implicated as candidate regulatory partners....
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