Article
Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.
EMBO reports - 1 Oct 2013
Christova Yonka, Adrain Colin, Bambrough Paul, Ibrahim Ashraf, Freeman Matthew
Abstract excerpt
Loss of iRhom2, a catalytically inactive rhomboid-like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in defective shedding of the cytokine tumor necrosis factor. Apart from the resulting inflammatory defects, iRhom2-null mice appear normal: they do not show the several defects seen in TACE knockouts, suggesting that TACE maturation is independent of iRhom2 in cells other than macrophages....
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