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Article

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases.

Open biology - 29 Mar 2019

Dulloo Iqbal, Muliyil Sonia, Freeman Matthew

Abstract excerpt

iRhom proteins are catalytically inactive relatives of rhomboid intramembrane proteases. There is a rapidly growing body of evidence that these pseudoenzymes have a central function in regulating inflammatory and growth factor signalling and consequent roles in many diseases. iRhom pseudoproteases have evolved new domains from their proteolytic ancestors, which are integral to their modular regulation and...

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Source

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Identifiers

PMID: 30890028
DOI: 10.1098/rsob.190003
PMCID: PMC6451368

Genes

ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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