Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.

doi:10.1007/s00018-024-05132-3

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Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.

Cellular and molecular life sciences : CMLS - 27 Feb 2024

Bläsius Katharina, Ludwig Lena, Knapp Sarah, Flaßhove Charlotte, Sonnabend Friederike, Keller Diandra, Tacken Nikola, Gao Xintong, Kahveci-Türköz Selcan, Grannemann Caroline, Babendreyer Aaron, Adrain Colin, Huth Sebastian, Baron Jens Malte, Ludwig Andreas, Düsterhöft Stefan

Abstract excerpt

The protease ADAM17 plays an important role in inflammation and cancer and is regulated by iRhom2. Mutations in the cytosolic N-terminus of human iRhom2 cause tylosis with oesophageal cancer (TOC). In mice, partial deletion of the N-terminus results in a curly hair phenotype (cub). These pathological consequences are consistent with our findings that iRhom2 is highly expressed in keratinocytes and in oesophageal...

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PMID: 38409522
DOI: 10.1007/s00018-024-05132-3
PMCID: PMC10896983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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