Article
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Science signaling - 3 Nov 2015
Maney Sathish K, McIlwain David R, Polz Robin, Pandyra Aleksandra A, Sundaram Balamurugan, Wolff Dorit, Ohishi Kazuhito, Maretzky Thorsten, Brooke Matthew A, Evers Astrid, Vasudevan Ananda A Jaguva, Aghaeepour Nima, Scheller Jürgen, Münk Carsten, Häussinger Dieter, Mak Tak W, Nolan Garry P, Kelsell David P, Blobel Carl P, Lang Karl S, Lang Philipp A
Abstract excerpt
The protease ADAM17 (a disintegrin and metalloproteinase 17) catalyzes the shedding of various transmembrane proteins from the surface of cells, including tumor necrosis factor (TNF) and its receptors. Liberation of TNF receptors (TNFRs) from cell surfaces can dampen the cellular response to TNF, a cytokine that is critical in the innate immune response and promotes programmed cell death but can also promote...
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