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Article

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

Journal of cell science - 1 Mar 2017

Li Xue, Maretzky Thorsten, Perez-Aguilar Jose Manuel, Monette Sébastien, Weskamp Gisela, Le Gall Sylvain, Beutler Bruce, Weinstein Harel, Blobel Carl P

Abstract excerpt

A disintegrin and metalloproteinase 17 (ADAM17) controls the release of the pro-inflammatory cytokine tumor necrosis factor α (TNFα, also known as TNF) and is crucial for protecting the skin and intestinal barrier by proteolytic activation of epidermal growth factor receptor (EGFR) ligands. The seven-membrane-spanning protein called inactive rhomboid 2 (Rhbdf2; also known as iRhom2) is required for...

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Identifiers

PMID: 28104813
DOI: 10.1242/jcs.196436
PMCID: PMC5358332

Genes

ADAM17
EGFR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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