Article

Identification of A Ribavirin–Resistant Ns5b Mutation of Hepatitis C Virus During Ribavirin Monotherapy

2003-10-01

Abstract excerpt

Ribavirin (RBV), a guanosine analogue, has been suggested to exert an antiviral action against hepatitis C virus (HCV) by causing lethal mutations and suppressing RNA polymerase in vitro , but the mechanism of its clinical therapeutic effects is currently unknown. To test the hypothesis that RBV could act both as an RNA mutagen and inhibit viral RNA synthesis in vivo , we studied the evolution of the nucleotide se...

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Literature Corpus work: a8f91177-cb1d-5d39-b328-a77d5e24aba2
DOI: 10.1002/hep.1840380413

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