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Article

Impacts of HBV rtH55R polymerase substitution on viral replication and rtM204I/V resistance to nucleoside/nucleotide antiviral drugs.

Antiviral therapy - 1 Jan 2018

Xiang Kuan-Hui, Zhao Cheng-Yu, Wang Shuai, Li Yao, Su Ming-Ze, Wang Qiang-Yi, Xu Xi-Zhan, Deng Juan, Zhuang Hui, Li Tong

Abstract excerpt

BACKGROUND: High genetic variability at the reverse transcriptase (RT) region of HBV could confer resistance to nucleoside/nucleotide analogues (NUCs). The aim of this study was to identify new RT amino acid (AA) substitutions related to NUC resistance. METHODS: HBV RT sequences of genotype C from 501 chronic hepatitis B (CHB) patients were analysed to identify potential RT substitutions related to NUC...

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Identifiers

PMID: 28440785
DOI: 10.3851/IMP3170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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