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Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase.

Hepatology (Baltimore, Md.) - 1 Mar 2001

Qin W, Yamashita T, Shirota Y, Lin Y, Wei W, Murakami S

Abstract excerpt

The hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRP), a central catalytic enzyme for HCV replication. To further understand the structure and functions of NS5B, we introduced a series of 27 clustered and 19 point substitution mutations within and outside the well-known motifs conserved among RdRP by alanine scanning and investigated effects of these mutants on...

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PMID: 11230755
DOI: 10.1053/jhep.2001.22765

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