Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin.

Microbes and infection - 1 Nov 2002

Crotty Shane, Andino Raul

Abstract excerpt

The antiviral drug ribavirin exhibits strong antiviral activity against a broad range of RNA viruses. This drug is currently used clinically to treat hepatitis C virus infections, respiratory syncytial virus infections, and Lassa fever virus infections. Although ribavirin was discovered in 1972, its mechanism of action has remained unclear until recently. Using poliovirus as an RNA virus model, it was shown that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Design
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutagenesis

Share to Poliovirus

Share to Ribavirin

Share to RNA Viruses

Source

Identifiers

PMID: 12443894
DOI: 10.1016/s1286-4579(02)00008-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin.PMID 12443894Read ↗

Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications.Semantic proximity Read ↗

RNA virus error catastrophe: direct molecular test by using ribavirin.Semantic proximity Read ↗

Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo.Semantic proximity Read ↗

Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin.Semantic proximity Read ↗

Mutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing Mutations.Semantic proximity Read ↗

Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load.Semantic proximity Read ↗

Advances Toward a Norovirus Antiviral: From Classical Inhibitors to Lethal MutagenesisSemantic proximity Read ↗

Back to the future: revisiting HIV-1 lethal mutagenesis.Semantic proximity Read ↗

Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesisSemantic proximity Read ↗

The three faces of riboviral spontaneous mutation: spectrum, mode of genome replication, and mutation rate.Semantic proximity Read ↗

Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir.Semantic proximity Read ↗

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside AnaloguesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.