Article
Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity.
Antimicrobial agents and chemotherapy - 17 Nov 2020
Mejer Niels, Fahnøe Ulrik, Galli Andrea, Ramirez Santseharay, Weiland Ola, Benfield Thomas, Bukh Jens
Abstract excerpt
Ribavirin has been used for 25 years to treat patients with chronic hepatitis C virus (HCV) infection; however, its antiviral mechanism of action remains unclear. Here, we studied virus evolution in a subset of samples from a randomized 24-week trial of ribavirin monotherapy versus placebo in chronic HCV patients, as well as the viral resistance mechanisms of the observed ribavirin-associated mutations in cell...
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