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Article

Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo.

Journal of virology - 1 Jun 2009

Cuevas José M, González-Candelas Fernando, Moya Andrés, Sanjuán Rafael

Abstract excerpt

Their extremely error-prone replication makes RNA viruses targets for lethal mutagenesis. In the case of hepatitis C virus (HCV), the standard treatment includes ribavirin, a base analog with an in vitro mutagenic effect, but the in vivo mode of action of ribavirin remains poorly understood. Here, we test the mutagenic effects of ribavirin plus interferon treatment in vivo using a new method to estimate mutation...

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Identifiers

PMID: 19321623
DOI: 10.1128/JVI.00201-09
PMCID: PMC2681971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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