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Article

Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C.

Journal of hepatology - 1 Oct 2005

Asahina Yasuhiro, Izumi Namiki, Enomoto Nobuyuki, Uchihara Masakatsu, Kurosaki Masayuki, Onuki Yuko, Nishimura Yuki, Ueda Ken, Tsuchiya Kaoru, Nakanishi Hiroyuki, Kitamura Takatoshi, Miyake Shozo

Abstract excerpt

BACKGROUND/AIMS: To elucidate whether ribavirin acts as a mutagen in the clinical setting and to clarify the relationship between ribavirin-induced mutations and virological response to combined therapy. METHODS: Thirty-four patients with hepatitis C virus (HCV) genotype 1b received ribavirin monotherapy for 4 weeks, followed by a 24-week course of IFN/ribavirin therapy. HCV mutations during a non-treatment...

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Source

Identifiers

PMID: 16098627
DOI: 10.1016/j.jhep.2005.05.032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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