Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a.

The Journal of general virology - 1 Aug 2018

Mejer Niels, Fahnøe Ulrik, Galli Andrea, Ramirez Santseharay, Benfield Thomas, Bukh Jens

Abstract excerpt

Ribavirin (RBV) has been used for the last 20 years to treat patients with chronic hepatitis C virus (HCV) infection. This pluripotent drug is believed to induce mutagenesis in HCV RNA. However, for cell-cultured HCV (HCVcc) this phenomenon has only been investigated in genotype 2a recombinants. Here we studied the mutations that developed in HCVcc of genotypes 1a and 3a treated with RBV or ribavirin triphosphate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Nucleic Acid Amplification Techniques

Share to Open Reading Frames

Share to Ribavirin

Share to Sofosbuvir

Share to Viral Proteins

Source

Identifiers

PMID: 29927371
DOI: 10.1099/jgv.0.001095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a.PMID 29927371Read ↗

Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model.Semantic proximity Read ↗

Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo.Semantic proximity Read ↗

Clinical mechanism of ribavirin action in Hepatitis C treatment: insights from the STOPHCV-1 randomised trialSemantic proximity Read ↗

Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system.Semantic proximity Read ↗

Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients.Semantic proximity Read ↗

Mutational spectrum of hepatitis C virus in patients with chronic hepatitis C determined by single molecule real-time sequencing.Semantic proximity Read ↗

Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity.Semantic proximity Read ↗

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin.Semantic proximity Read ↗

A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus.Semantic proximity Read ↗

Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy.Semantic proximity Read ↗

Analysis of Ribavirin Mutagenicity in Human Hepatitis C Virus InfectionSemantic proximity Read ↗

Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.