Article

Chromatin 3D interaction analysis of the <i>STARD10</i> locus unveils <i>FCHSD2</i> as a new regulator of insulin secretion

2020-04-01

Abstract excerpt

<h4>SUMMARY</h4> Genome-wide association studies have identified thousands of genetic variants associated with type 2 diabetes (T2D) risk. Using chromatin conformation capture we show that an enhancer cluster in the STARD10 T2D locus forms a defined 3D chromatin domain. A 4.1 Kb region within this region, carrying five disease-associated variants, physically interacts with CTCF-binding regions and with an enhanc...

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Literature Corpus work: a8c9e51d-b7a6-5552-8c7b-4cfee50c89fd
DOI: 10.1101/2020.03.31.017707

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Chromatin 3D interaction analysis of the <i>STARD10</i> locus unveils <i>FCHSD2</i> as a new regulator of insulin secretionDOI 10.1101/2020.03.31.017707Read

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