Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

doi:10.1016/j.ajhg.2017.01.011

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

American journal of human genetics - 2 Feb 2017

Carrat Gaelle R, Hu Ming, Nguyen-Tu Marie-Sophie, Chabosseau Pauline, Gaulton Kyle J, van de Bunt Martijn, Siddiq Afshan, Falchi Mario, Thurner Matthias, Canouil Mickaël, Pattou Francois, Leclerc Isabelle, Pullen Timothy J, Cane Matthew C, Prabhala Priyanka, Greenwald William, Schulte Anke, Marchetti Piero, Ibberson Mark, MacDonald Patrick E, Manning Fox Jocelyn E, Gloyn Anna L, Froguel Philippe, Solimena Michele, McCarthy Mark I, Rutter Guy A

Abstract excerpt

Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin conversion. Neither the identity of the causal variants nor the gene(s) through which risk is conferred have been firmly established....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Insulin

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to Phosphoproteins

Share to Proinsulin

Share to Steroidogenic Acute Regulatory Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28132686
DOI: 10.1016/j.ajhg.2017.01.011
PMCID: PMC5294761

Genes

STARD10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.PMID 28132686Read ↗

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.Semantic proximity Read ↗

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.Semantic proximity Read ↗

Chromatin 3D interaction analysis of the <i>STARD10</i> locus unveils <i>FCHSD2</i> as a new regulator of insulin secretionSemantic proximity Read ↗

Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin ResistanceSemantic proximity Read ↗

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genesSemantic proximity Read ↗

Comparative Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Insights into Type 2 Diabetes GeneticsSemantic proximity Read ↗

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation.Semantic proximity Read ↗

An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 DiabetesSemantic proximity Read ↗

Genetic regulation of RNA splicing in human pancreatic isletsSemantic proximity Read ↗

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.Semantic proximity Read ↗

A functional variant rs912304 for late-onset T1D risk contributes to islet dysfunction by regulating proinflammatory cytokine-responsive gene STXBP6 expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.