Article

Pancreatic islet chromatin accessibility and conformation defines distal enhancer networks of type 2 diabetes risk

2018-04-20

Abstract excerpt

The gene targets of enhancer activity in pancreatic islets are largely unknown, impeding discovery of islet regulatory networks involved in type 2 diabetes (T2D) risk. We mapped chromatin state, accessibility and conformation using ChIP-seq, ATAC-seq and Hi-C in human pancreatic islets, which we integrated with T2D genetic fine-mapping and islet expression QTL data. Active islet regulatory elements preferentially...

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Literature Corpus work: 301a77b1-885e-5a53-bc6f-951139aa6b6a
DOI: 10.1101/299388

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