Article

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

2018-08-27

Abstract excerpt

Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer regions (enhancer clusters, stretch enhancers or super-enhancers). So far, such domains have been defined through clustering of enhancers in linear genome maps rather than in 3D-space. Furthermore, their target genes are generally unkn...

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Literature Corpus work: 4a145710-e875-5208-8344-6536e3bc3bdd
DOI: 10.1101/400291

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