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Article

Implicating type 2 diabetes effector genes in relevant metabolic cellular models using promoter-focused Capture-C.

Diabetologia - 1 Dec 2024

Wachowski Nicholas A, Pippin James A, Boehm Keith, Lu Sumei, Leonard Michelle E, Manduchi Elisabetta, Parlin Ursula W, Wabitsch Martin, Chesi Alessandra, Wells Andrew D, Grant Struan F A, Pahl Matthew C

Abstract excerpt

AIMS/HYPOTHESIS: Genome-wide association studies (GWAS) have identified hundreds of type 2 diabetes loci, with the vast majority of signals located in non-coding regions; as a consequence, it remains largely unclear which 'effector' genes these variants influence. Determining these effector genes has been hampered by the relatively challenging cellular settings in which they are hypothesised to confer their...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39240351
DOI: 10.1007/s00125-024-06261-x
PMCID: PMC11604697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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