Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of functional enhancer variants associated with type I diabetes in CD4+ T cells.

Frontiers in immunology - 1 Jan 2024

Mishra Arpit, Jajodia Ajay, Weston Eryn, Jayavelu Naresh Doni, Garcia Mariana, Hossack Daniel, Hawkins R David

Abstract excerpt

Type I diabetes is an autoimmune disease mediated by T-cell destruction of β cells in pancreatic islets. Currently, there is no known cure, and treatment consists of daily insulin injections. Genome-wide association studies and twin studies have indicated a strong genetic heritability for type I diabetes and implicated several genes. As most strongly associated variants are noncoding, there is still a lack of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Lectins, C-Type

Share to Quantitative Trait Loci

Share to Suppressor of Cytokine Signaling 1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 38947339
DOI: 10.3389/fimmu.2024.1387253
PMCID: PMC11211866

Genes

CD4
CLEC16A
SOCS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of functional enhancer variants associated with type I diabetes in CD4+ T cells.PMID 38947339Read ↗

A comprehensive integrated post-GWAS analysis of Type 1 diabetes reveals enhancer-based immune dysregulation.Semantic proximity Read ↗

CRISPR Screening Uncovers a Long-Range Enhancer for <i>ONECUT1</i> in Pancreatic Differentiation and Links a Diabetes Risk VariantSemantic proximity Read ↗

CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variantSemantic proximity Read ↗

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cellsSemantic proximity Read ↗

Integration of genetic and epigenetic data pinpoints autoimmune specific remodelling of enhancer landscape in CD4+ T cellsSemantic proximity Read ↗

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.Semantic proximity Read ↗

Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes riskSemantic proximity Read ↗

Integration of genetic and chromatin modification data pinpoints autoimmune-specific remodeling of enhancer landscape in CD4+ T cells.Semantic proximity Read ↗

Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cellsSemantic proximity Read ↗

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screensSemantic proximity Read ↗

3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk.Semantic proximity Read ↗

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.