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ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes

23 May 2019

Abstract excerpt

Impaired insulin secretion from pancreatic islets is a hallmark of type 2 diabetes (T2D). Altered chromatin structure may contribute to the disease. We therefore studied the impact of T2D on open chromatin in human pancreatic islets. We used assay for transposase-accessible chromatin using sequencing (ATAC-seq) to profile open chromatin in islets from T2D and non-diabetic donors. We identified 57,105 and 53,284...

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PMID: 31123324
DOI: 10.1038/s41598-019-44076-8

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