Article

CRISPR Screening Uncovers a Long-Range Enhancer for <i>ONECUT1</i> in Pancreatic Differentiation and Links a Diabetes Risk Variant

2024-04-29

Abstract excerpt

Functional enhancer annotation is a valuable first step for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants for investigation. However, unbiased enhancer discovery in physiologically relevant contexts remains a major challenge. To discover regulatory elements pertinent to diabetes, we conducted a CRISPR interference screen in the human pluripotent st...

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Literature Corpus work: 097a5fbb-2535-5078-bc9d-1c24173e0e92
DOI: 10.1101/2024.04.26.591412

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CRISPR Screening Uncovers a Long-Range Enhancer for <i>ONECUT1</i> in Pancreatic Differentiation and Links a Diabetes Risk VariantDOI 10.1101/2024.04.26.591412Read

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