Article

New insights into the <i>cis</i> -regulation of the <i>CFTR</i> gene in pancreatic cells

2025-01-19

Abstract excerpt

<h4>Background</h4> Spatial organization of the genome is fundamental for ensuring accurate gene expression. This process depends on the communication between gene promoters and distal cis -regulatory elements (CREs), which together make up 8% of the human genome and are supported by the chromatin structure. It is estimated that over 90% of disease-associated variants are located in the non-coding region of the...

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Literature Corpus work: 11db6269-6366-5431-a5f7-376e52f288a4
DOI: 10.1101/2025.01.14.632890

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