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Article

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence

2024-09-03

Abstract excerpt

Mitochondria have evolved a specialized mitochondrial unfolded protein response (UPR mt ) to maintain proteostasis and promote recovery under stress. Studies in simple organisms have shown that UPR mt activation in glial cells supports proteostasis through beneficial noncell-autonomous communication with neurons. However, the role of mitochondrial stress responses in the human brain remains unclear. To address t...

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Identifiers and source

Literature Corpus work
a8a0afbb-c9c7-559c-91f7-b31106b93afc
DOI
10.1101/2024.09.03.610925
Open publication

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The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescenceDOI 10.1101/2024.09.03.610925
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