Article

PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal death

2026-06-09

Abstract excerpt

Genetic loss of the mitochondrial control enzyme PINK1 leads to Parkinson’s disease, characterized by dopaminergic neuron degeneration and neuroinflammation, yet its role in glia remains poorly understood. To address this gap, we investigated how the function of astrocytes and their ability to support neurons is influenced by PINK1 deficiency. For the first time, we demonstrate that human astrocytes exhibit robust...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5128d296-4409-50c5-aa04-531b2b9d4c14
DOI: 10.64898/2026.06.04.729996

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal deathDOI 10.64898/2026.06.04.729996Read

PINK1/Parkin-dependent mitophagy mediates astrocytic inflammatory responses to mitochondrial damageSemantic proximity Read

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's DiseaseSemantic proximity Read

Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?Semantic proximity Read

A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's diseaseSemantic proximity Read

Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG MutationsSemantic proximity Read

Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson’s Tri-Culture ModelSemantic proximity Read

Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.Semantic proximity Read

Proteostasis dysregulation in p.A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson’s disease model with Lewy-like pathologySemantic proximity Read

Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutationSemantic proximity Read

Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation.Semantic proximity Read

Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3.Semantic proximity Read

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signalingSemantic proximity Read