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Senescent Astrocytes Derived from Human Pluripotent Stem Cells Reveal Age-Related Changes and Implications for Neurodegeneration

1 Jan 2024

Abstract excerpt

Astrocytes play a crucial role in maintaining brain homeostasis by regulating synaptic activity, providing metabolic support to neurons, and modulating immune responses in the central nervous system (CNS). During aging, astrocytes undergo senescence with various changes that affect their function and frequently lead to neurodegeneration. This study presents the first evidence of senescent astrocytes derived from...

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Share to Genetics, Aging, and Longevity in Model Organisms
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 38913048
DOI: 10.14336/ad.2024.0089

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