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Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

2026-06-08

Abstract excerpt

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architecture of this network, we conducted unbiased genetic interaction screens using the Cas12a genome editor to disrupt 233 DDR genes frequently mutated in cancer and other genetic diseases, either individually or in pairwis...

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Identifiers and source

Literature Corpus work
a87ba776-55da-59bd-9e6a-e72c69d939f2
DOI
10.64898/2026.06.07.728858
Open publication

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Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screensDOI 10.64898/2026.06.07.728858
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