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Article

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens.

Molecular oncology - 1 Nov 2022

Wilson Jordan, Loizou Joanna I

Abstract excerpt

The concepts of synthetic lethality and viability have emerged as powerful approaches to identify vulnerabilities and resistances within the DNA damage response for the treatment of cancer. Historically, interactions between two genes have had a longstanding presence in genetics and have been identified through forward genetic screens that rely on the molecular basis of the characterized phenotypes, typically...

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Identifiers

PMID: 35708734
DOI: 10.1002/1878-0261.13272
PMCID: PMC9627789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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