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Mapping the genetic landscape of DNA double-strand break repair.

Cell - 28 Oct 2021

Hussmann Jeffrey A, Ling Jia, Ravisankar Purnima, Yan Jun, Cirincione Ann, Xu Albert, Simpson Danny, Yang Dian, Bothmer Anne, Cotta-Ramusino Cecilia, Weissman Jonathan S, Adamson Britt

Abstract excerpt

Cells repair DNA double-strand breaks (DSBs) through a complex set of pathways critical for maintaining genomic integrity. To systematically map these pathways, we developed a high-throughput screening approach called Repair-seq that measures the effects of thousands of genetic perturbations on mutations introduced at targeted DNA lesions. Using Repair-seq, we profiled DSB repair products induced by two...

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Identifiers

PMID: 34672952
DOI: 10.1016/j.cell.2021.10.002
PMCID: PMC9074467

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