Article

A genetic map of the response to DNA damage in human cells

2019-11-18

Abstract excerpt

<h4>SUMMARY</h4> The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity and gametogenesis. In order to provide an unbiased and global view of the DNA damage response in human cells, we undertook 28 CRISPR/Cas9 screens against 25 genotoxic agents in the retinal pigment epithelium-1 (RPE1) cell line. These screens identified 840 genes whose loss causes either sensitivity or res...

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Literature Corpus work: bd2b97bf-a18a-5b93-89cd-ddcf86bb7ad5
DOI: 10.1101/845446

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