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Article

Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens.

Molecular cell - 3 Aug 2023

Zhao Yichao, Tabet Daniel, Rubio Contreras Diana, Lao Linjiang, Kousholt Arne Nedergaard, Weile Jochen, Melo Henrique, Hoeg Lisa, Feng Sumin, Coté Atina G, Lin Zhen-Yuan, Setiaputra Dheva, Jonkers Jos, Gingras Anne-Claude, Gómez Herreros Fernando, Roth Frederick P, Durocher Daniel

Abstract excerpt

To maintain genome integrity, cells must accurately duplicate their genome and repair DNA lesions when they occur. To uncover genes that suppress DNA damage in human cells, we undertook flow-cytometry-based CRISPR-Cas9 screens that monitored DNA damage. We identified 160 genes whose mutation caused spontaneous DNA damage, a list enriched in essential genes, highlighting the importance of genomic integrity for...

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Identifiers

PMID: 37478847
DOI: 10.1016/j.molcel.2023.06.025
PMCID: PMC10530064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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