Article

A consensus set of genetic vulnerabilities to ATR inhibition

2019-03-12

Abstract excerpt

The response to DNA replication stress in eukaryotes is under the control of the ataxia-telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to stabilize distressed DNA replication forks, modulate DNA replication firing and prevent cells with damaged DNA or incomplete DNA replication from entering into mitosis. Furthermore, inhibitors of ATR are currently in clinical development e...

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Literature Corpus work: 52ced652-6f3d-5ec5-8f7c-1f6121c9a25b
DOI: 10.1101/574533

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