Article

FANCA Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 Inhibitors

2025-07-03

Abstract excerpt

<title>Abstract</title> <p>Synthetic lethality (SL) underlies the success of PARP1 inhibitors (PARPi) in treating homologous recombination (HR) deficient cancers, but extending this paradigm to other DNA damage response (DDR) deficiencies has proven challenging. We performed an in vivo CRISPR screen to identify DDR gene mutations that both enhance tumorigenesis and confer sensitivity to PARPi. Our screen identifi...

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Literature Corpus work: 6e1b1d34-188f-5901-8918-ae3ff1abc44a
DOI: 10.21203/rs.3.rs-6080272/v1

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FANCA Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 InhibitorsDOI 10.21203/rs.3.rs-6080272/v1Read

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