Article

Elevated α-synuclein attenuates phagocytosis in <i>SNCA</i> triplication human iPSC-derived neuron:microglia co-cultures

2022-11-15

Abstract excerpt

Synucleinopathies such as Parkinson’s disease (PD) are characterized by pathologic production, aggregation, and cell-to-cell transmission of α-synuclein (α-syn) protein that results in impaired cellular function. While neurons of the substantia nigra pars compacta express high levels of α-synuclein and are highly vulnerable to its aberrant expression or conformation, brain-resident macrophages (microglia) are also...

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Literature Corpus work: a7f5aa11-dbf0-52e8-845e-d1ea28f180a8
DOI: 10.1101/2022.11.15.516591

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