Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.

doi:10.1073/pnas.2505240122

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Article

Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2025

Paschou Christina, Apokotou Olympia, Charmpi Konstantina, Kollias Anastasios, Dede Sofia, Samiotaki Martina, Koutsoudaki Paraskevi N, Havaki Sophia, Palese Francesca, Dimoula Konstantina, Emmanouilidou Evangelia, Gorgoulis Vassilis G, Taoufik Era, Zurzolo Chiara, Matsas Rebecca, Papastefanaki Florentia

Abstract excerpt

Alpha-Synuclein (αSyn) plays a central role in Parkinson's disease (PD), and the p.A53T mutation causes an early-onset familial form of PD with severe manifestations. While its effects on neurons are well studied, its consequences on astrocytes and astrocytic contribution to PD pathology are understudied. Here, we differentiated patient-derived p.A53T-αSyn induced pluripotent stem cells (iPSC) to ventral midbrain...

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Identifiers

PMID: 41248289
DOI: 10.1073/pnas.2505240122
PMCID: PMC12664016

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