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Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

15 Aug 2017

Abstract excerpt

To examine the pathogenic role of α-synuclein (αS) in Parkinson's Disease, we have generated induced Pluripotent Stem Cell lines from early onset Parkinson's Disease patients with SNCA A53T and SNCA Triplication mutations, and in this study have differentiated them to PSC-macrophages (pMac), which recapitulate many features of their brain-resident cousins, microglia. We show that SNCA Triplication pMac, but not...

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PMID: 28827786
DOI: 10.1038/s41598-017-09362-3

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